The effect of rifampicin on sulphapyridine plasma concentrations following sulphasalazine administration.
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منابع مشابه
Comparison of the single dose pharmacokinetics of sulphasalazine in rheumatoid arthritis and inflammatory bowel disease.
The pharmacokinetics of sulphasalazine and its principal metabolites in rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) were compared. Patients with RA had a significantly greater concentration of plasma sulphapyridine than patients with IBD (medians 14.0 micrograms/ml and 7.4 micrograms/ml respectively). Patients with RA also tended to maintain a higher plasma sulphapyridine con...
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Acocella, G. (1978). Clinical pharmacokinetics of rifampicin. Clin. Pharmacokin., 3, 108-127. Binda, G., Domenichini, E., Gottardi, A., Orlandi, B., Ortelli, E., Pacini, B. & Fowst, G. (1971). Rifampicin, a general review. Arzneim-Forsch., 21, 1907-1977. Conney, A. H. (1967). Pharmacological implications of microsomal induction. Pharmac. Rev., 19, 317366. Das, K. M. & Dubin, R. (1976). Clinical...
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Sulphasalazine treatment for inflammatory bowel disease in man causes oligospermia, reduced sperm motility and an increased proportion of abnormal forms. On withdrawal of sulphasalazine these effects are found to be reversible and 15 pregnancies occurred at a median of 2.5 months after stopping sulphasalazine therapy. Seminal plasma concentrations of acid phosphatase fructose and PGE2 as well a...
متن کاملAcetylator phenotype and adverse effects of sulphasalazine in healthy subjects.
Sulphasalazine (salicyl-azo-sulphapyridine) was ingested by 27 healthy subjects for five days at a dosage of 4 g daily. The acetylator phenotype of each subject had been established previously. The serum concentrations of the parent drug and its sulphapyridine-metabolites were determined and the adverse effects were recorded. There was no correlation between the serum concentrations of sulphasa...
متن کاملControlled trial of rifampicin and ethambutol in Crohn's disease.
We pursued the possibility that Mycobacterium kansasii might be an aetiological agent in Crohn's disease by carrying out a trial of treatment with antimycobacterial drugs. Twenty seven patients with Crohn's disease took part in a two year randomised double blind, crossover, controlled trial of rifampicin plus ethambutol against placebo. Fourteen patients completed the trial; four required an op...
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عنوان ژورنال:
- British journal of clinical pharmacology
دوره 19 4 شماره
صفحات -
تاریخ انتشار 1985